Binding of Prostaglandin E1 to Beef Thyroid Membranes
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چکیده
منابع مشابه
Thyroid-stimulating Hormone Binding to Beef Thyroid Membranes
The effect of sugars on ‘*“I-thyroid-stimulating hormone binding to beef thyroid membranes was studied to determine their role in thyroid-stimulating hormone (TSH) binding. At 0.1 M concentration, N-acetylneuraminic acid produced a 3to 7-fold increase in TSH binding, was the only sugar to enhance TSH binding, and did so whether binding was determined in the cyclase medium or under conditions of...
متن کاملThyroid-stimulating Hormone Binding to Beef Thyroid Membranes RELATIOK TO ADENYLATE CYCLASE ACTIVITY
Binding of [3H]thyroid-stimulating hormone (TSH) and iz51-TSH to beef thyroid membranes was studied under conditions to give optimum binding. Binding was maximal at pH 5.5, was complete within 5 min, and was stable for at least 90 min at 0 and 22” for low and high TSH concentrations, respectively. At pH 7.5, two binding sites were found with apparent affinity constants of 2.2 to 3.1 X lo8 M-I a...
متن کاملThyroid-stimulating hormone binding to beef thyroid membranes. Relation to adenylate cyclase activity.
Binding of [3H]thyroid-stimulating hormone (TSH) and iz51-TSH to beef thyroid membranes was studied under conditions to give optimum binding. Binding was maximal at pH 5.5, was complete within 5 min, and was stable for at least 90 min at 0 and 22” for low and high TSH concentrations, respectively. At pH 7.5, two binding sites were found with apparent affinity constants of 2.2 to 3.1 X lo8 M-I a...
متن کاملThyroid-stimulating hormone binding to beef thyroid membranes. Role of N-acetylneuraminic acid.
The effect of sugars on 125I-thyroid-stimulating hormone binding to beef thyroid membranes was studied to determine their role in thyroid-stimulating hormone (TSH) binding. At 0.1 M concentration, N-acetylneuraminic acid produced a 3- to 7-fold increase in TSH binding, was the only sugar to enhance TSH binding, and did so whether binding was determined in the cyclase medium or under conditions ...
متن کاملCortical hyperostosis secondary to prolonged use of prostaglandin E1.
Prostaglandin E1 (Alprostadil), a drug used for ductal patency in cyanotic congenital heart disease, comprises an essential part of the treatment of infants waiting for cardiac surgery in hospitals with no specialized medical staff or in situations of inadequate weight for surgery. Prostaglandin E1 (PgE1) can also be used in elevation of presurgical oxygenation status in more severe cases. The ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1973
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)43562-x